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National Institutes of Health

HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied…

Agency
National Institutes of Health
Deadline
Jul 16, 2026 (4 days left)
Award ceiling
$100,000
Opportunity #
PAR-25-154
CFDA
93.121, 93.213, 93.273, 93.279, 93.350, 93.846, 93.853, 93.865, 93.866
Cost sharing
Not required
EducationHealthIncome Security and Social ServicesPublic and State controlled institutions of higher educationIndependent school districtsPublic housing authorities/Indian housing authoritiesNative American tribal organizations (other than Federally recognized tribal governments)Small businessesFor profit organizations other than small businessesNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationOthers (see text field entitled "Additional Information on Eligibility" for clarification)Special district governmentsPrivate institutions of higher educationCity or township governmentsCounty governmentsState governmentsNative American tribal governments (Federally recognized)

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About this opportunity

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO.

This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain.

This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal…

How to apply

Applications for federal grants are submitted through grants.gov under opportunity number PAR-25-154. Before you start, confirm your organization's eligibility, register in SAM.gov if you haven't already, and note the response deadline of Jul 16, 2026. AutoGrantHunter helps you decide whether this opportunity is worth pursuing before you invest in a full application.

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