National Institutes of Health · Closed

HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied…

This grant opportunity has closed (deadline Jul 16, 2026). Applications are no longer being accepted on grants.gov. Explore related open grants below, or use Grant Match to find current opportunities you qualify for.

Agency

National Institutes of Health

Deadline

Closed Jul 16, 2026

Award ceiling

$100,000

Opportunity #

PAR-25-154

CFDA

93.121, 93.213, 93.273, 93.279, 93.350, 93.846, 93.853, 93.865, 93.866

Cost sharing

Not required

Education Health Income Security and Social Services City or township governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized)Others (see text field entitled "Additional Information on Eligibility" for clarification)Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments)Independent school districts Special district governments Public housing authorities/Indian housing authorities County governments

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About this opportunity

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO.

This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain.

This NOFO is part of the NIH Helping to End Addiction Long Term (HEAL) initiative to accelerate the development of novel medications to treat all aspects of the opioid addiction cycle, including progression to chronic use, withdrawal symptoms, craving, relapse, and overdose.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal…

How to apply

Applications for federal grants are submitted through grants.gov under opportunity number PAR-25-154. Before you start, confirm your organization's eligibility, register in SAM.gov if you haven't already, and note the former response deadline of Jul 16, 2026. AutoGrantHunter helps you decide whether this opportunity is worth pursuing before you invest in a full application.

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