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National Institutes of Health

Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required)

This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to…

Agency
National Institutes of Health
Deadline
Jul 14, 2026 (2 days left)
Opportunity #
PAR-24-275
CFDA
93.213
Cost sharing
Not required
HealthPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Public housing authorities/Indian housing authoritiesOthers (see text field entitled "Additional Information on Eligibility" for clarification)County governmentsSpecial district governmentsFor profit organizations other than small businessesCity or township governmentsIndependent school districtsNonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationState governmentsNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationSmall businessesNative American tribal organizations (other than Federally recognized tribal governments)Private institutions of higher education

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About this opportunity

This notice of funding opportunity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority.

Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial.

CCC applications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism.

In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH.

For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans).

Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal…

How to apply

Applications for federal grants are submitted through grants.gov under opportunity number PAR-24-275. Before you start, confirm your organization's eligibility, register in SAM.gov if you haven't already, and note the response deadline of Jul 14, 2026. AutoGrantHunter helps you decide whether this opportunity is worth pursuing before you invest in a full application.

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